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Daniel Ricquier
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'''Daniel Ricquier''', born on May 19, 1949, is a French [[biochemist]] specializing in [[Mitochondrion|mitochondria]] and hereditary [[Metabolic disorder|metabolic diseases]]<ref name=":0"> Liste des membres de l'Académie des sciences / R Listes par ordre alphabétique Listes des membres Membres Nous connaître|url=http://www.academie-sciences.fr/fr/Liste-des-membres-de-l-Academie-des-sciences-/-R/daniel-ricquier.html|site=www.academie-sciences.fr|consulté le=2017-01-23}}</ref>. He has been a member of the French Academy of sciences since 2002<ref name=":0" /> and Professor of Biochemistry and [[Molecular biology|Molecular Biology]] at the Faculty of Medicine of the [[Paris Descartes University|University of Paris Descartes]] since 2003<ref></ref>. [[File:Daniel Ricquier.jpg|thumb|Daniel Riquier - December 2016]]
== Biography ==
Daniel Ricquier, is a university professor and exceptional class hospital practitioner at faculté́ of medicine at the University of Paris-Descartes and at the [[Necker-Enfants Malades Hospital|Necker-Enfants malades Hospital]]<ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> since 2003.
He directed the "Centre de recherche sur l'endocrinologie moléculaire et le développement" of the [[French National Centre for Scientific Research|CNRS]] in Meudon from 1997 to 2002, then the CNRS unit "Biologie des Transporteurs mitochondriaux et métabolisme" from 2002 to 2008 at faculté́ de médecine Necker Paris Descartes and at the Institut de recherches Necker-Enfants Malades. He was Head of the Metabolic Biochemistry Department at Necker Enfants Malades Hospital and at AP-HP from 2003 to 2014. He was elected a member of the Academy of Sciences on 19 November 2002<ref name=":0" />.
== Scientific Works ==
Daniel Ricquier specializes in the [[physiology]] and biochemistry of mitochondria, [[adipose tissue]] and [[Thermogenics|thermogenic]] mechanisms. He is an expert on [[brown adipose tissue]]. His work has contribué́ to identify a family of proteins involved in mitochondrial respiration, [[ATP]] yield, heat production and mitochondrial control of the level of cellular oxygenated [[free radicals]].
Daniel Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes<ref><abbr>(en)</abbr> Ricquier D., Kader J.C, « Mitochondrial protein alteration in active brown fat. A sodium dodecyl sulfate- polyacrylamide gel electrophoretic study », ''Biochem. Biophys'', 1976</ref>, later named UCP ([[uncoupling protein]]) and identified by David Nicholls as the protein responsible for [[heat energy]] dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in [[neonates]] and adult patients and demonstrated that the [[sympathetic nervous system]] controls the development of brown adipose tissue and the synthesis of DCS in animals and humans<ref><abbr>(en)</abbr> Ricquier D., Néchad M., Mory G, « Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma », ''J. Clin. Endocrinol. Metab'', 1982, <abbr>p.</abbr> 805 - 807</ref>. With Fréderic Bouillaud, in 1984 and in collaboration with [[Jean Weissenbach]] at the [[Pasteur Institute]], he isolated and sequenced the complementary [[DNA]] of the UCP and the UCP gene from rodents and humans<ref><abbr>(en)</abbr> Bouillaud F., Ricquier D., Thibault J., Weissenbach J., « Molecular approach to thermogenesis in brown adipose tissue : cDNA cloning of the mitochondrial uncoupling protein », ''Proc. Natl. Acad. Sci. USA'', 1985, <abbr>p.</abbr> 445 - 448</ref>. He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein<ref><abbr>(en)</abbr> Cassard-Doulcier A-M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D., « Tissue-specific and ß-adrenergic regulation of the mitochondrial uncoupling protein gene - Control by cis-acting elements in the 5'-flanking region. », ''Mol. Endocrinol'', 1993, <abbr>p.</abbr> 497-506</ref> <ref><abbr>(en)</abbr> Miroux B., Frossart V., Raimbault S., Ricquier D., Bouillaud F., « The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins », ''EMBO J. 12'', 1993, <abbr>p.</abbr> 3739-3745</ref> <ref><abbr>(en)</abbr> Bouillaud F., Arechaga I., Petit P.X., Lévi-Meyrueis C., Casteilla L., Laurent M., Rial E., Ricquier D., « A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of the proton transport through the mitochondrial uncoupling protein », ''EMBO J 13'', 1994, <abbr>p.</abbr> 1990-1997</ref>.
Daniel Ricquier identified and characterized in 1997 a second UCP protein called UCP2<ref name=":1"><abbr>(en)</abbr> Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Lévi- Meyrueis C., Bouillaud F., Seldin MF, Surwit RS, Ricquier D., Warden CH., « Uncoupling Protein-2 : a new thermogenic protein and a new gene linked to obesity and hyperinsulism », ''Nature Genetics 15'', 1997, <abbr>p.</abbr> 269-272</ref>, the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP<ref>D. Sanchis, C. Fleury, N. Chomiki et M. Goubern, « BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 273, <abbr>n<sup>o</sup></abbr> 51, 18 décembre 1998, <abbr>p.</abbr> 34611–34615 <small>(ISSN 0021-9258, <nowiki>PMID 9852133</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref> , an avian UCP<ref>S. Raimbault, S. Dridi, F. Denjean et J. Lachuer, « An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds », ''The Biochemical Journal'', <abbr>vol.</abbr> 353, <abbr>n<sup>o</sup></abbr> Pt 3, <abbr>1<sup>er</sup></abbr> février 2001, <abbr>p.</abbr> 441–444 <small>(ISSN 0264-6021, <nowiki>PMID 11171038</nowiki>, PMCID PMC1221587, lire en ligne, consulté le 21 juillet 2017)</small></ref> and a renal mitochondrial transporter KMCP<ref>Anne Haguenauer, Serge Raimbault, Sandrine Masscheleyn et Maria del Mar Gonzalez-Barroso, « A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 280, <abbr>n<sup>o</sup></abbr> 23, 10 juin 2005, <abbr>p.</abbr> 22036–22043 <small>(ISSN 0021-9258, <nowiki>PMID 15809292</nowiki>, DOI 10.1074/jbc.M412136200, lire en ligne, consulté le 21 juillet 2017)</small></ref> and contributed to the identification of the first plant UCP protein<ref><abbr>(en)</abbr> Laloi M., Klein M., Resmeier J.W., Fleury C, Bouillaud F., Ricquier D., « A plant cold-induced uncoupling protein », ''Nature 389'', 1997, <abbr>p.</abbr> 135-136</ref>. He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels<ref>D. Arsenijevic, H. Onuma, C. Pecqueur et S. Raimbault, « Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production », ''Nature Genetics'', <abbr>vol.</abbr> 26, <abbr>n<sup>o</sup></abbr> 4, décembre 2000, <abbr>p.</abbr> 435–439 <small>(ISSN 1061-4036, <nowiki>PMID 11101840</nowiki>, DOI 10.1038/82565, lire en ligne, consulté le 21 juillet 2017)</small></ref> <ref>Marie-Clotilde Alves-Guerra, Sophie Rousset, Claire Pecqueur et Ziad Mallat, « Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 278, <abbr>n<sup>o</sup></abbr> 43, 24 octobre 2003, <abbr>p.</abbr> 42307–42312 <small>(ISSN 0021-9258, <nowiki>PMID 12907675</nowiki>, DOI 10.1074/jbc.M306951200, lire en ligne, consulté le 21 juillet 2017)</small></ref> <ref>Yalin Emre, Corinne Hurtaud, Tobias Nübel et François Criscuolo, « Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages », ''The Biochemical Journal'', <abbr>vol.</abbr> 402, <abbr>n<sup>o</sup></abbr> 2, <abbr>1<sup>er</sup></abbr> mars 2007, <abbr>p.</abbr> 271–278 <small>(ISSN 1470-8728, <nowiki>PMID 17073824</nowiki>, PMCID PMC1798432, DOI 10.1042/BJ20061430, lire en ligne, consulté le 21 juillet 2017)</small></ref> , particularly in macrophages in collaboration with Denis Richard at [[Université Laval|Laval University]]. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis<ref>J. Blanc, M. C. Alves-Guerra, B. Esposito et S. Rousset, « Protective role of uncoupling protein 2 in atherosclerosis », ''Circulation'', <abbr>vol.</abbr> 107, <abbr>n<sup>o</sup></abbr> 3, 28 janvier 2003, <abbr>p.</abbr> 388–390 <small>(ISSN 1524-4539, <nowiki>PMID 12551860</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref>.
Daniel Ricquier has demonstrated that mutations in the UCP2 protein induce congenital [[hyperinsulinism]] in children at birth<ref>M. Mar González-Barroso, Irina Giurgea, Fredéric Bouillaud et Andrea Anedda, « Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion », ''PloS One'', <abbr>vol.</abbr> 3, <abbr>n<sup>o</sup></abbr> 12, 2008, e3850 <small>(ISSN 1932-6203, <nowiki>PMID 19065272</nowiki>, PMCID PMC2588657, DOI 10.1371/journal.pone.0003850, lire en ligne, consulté le 21 juillet 2017)</small></ref>. He also described a protective role for UCP2 against autoimmune diabetes<ref>Yalin Emre, Corinne Hurtaud, Melis Karaca et Tobias Nubel, « Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes », ''Proceedings of the National Academy of Sciences of the United States of America'', <abbr>vol.</abbr> 104, <abbr>n<sup>o</sup></abbr> 48, 27 novembre 2007, <abbr>p.</abbr> 19085–19090 <small>(ISSN 1091-6490, <nowiki>PMID 18006654</nowiki>, PMCID PMC2141912, DOI 10.1073/pnas.0709557104, lire en ligne, consulté le 21 juillet 2017)</small></ref>. Applications of the work include metabolic diseases (obesity, diabetes), nutrition, [[Degenerative disease|degenerative diseases]] and [[Autoimmune disease|autoimmune diseases]] involving oxygenated free radicals in [[atherosclerosis]] and [[neurodegeneration]].
== Honours and Awards ==
* 1988: Paul Langevin Prize from the French Academy of sciences
* 1989: [[CNRS Silver Medal|CNRS silver medal]]
* 1995: F. Wasserman Medal of the European Association for the Study of Obesity<ref></ref>
* 2000: Grand Prix des industries agro-alimentaires from the French Academy of sciences
* 2002: Member of the French Academy of sciences<ref name=":0" />
* 2002: Wertheimer Medal from the International Association of Study on Obesity
* 2013: Chevalier in the Ordre de la Légion d'Honneur<ref><small>Décret du 29 mars 2013 portant promotion et nomination</small></ref>
* 2012-2017: Deputy Vice-President for International Relations of the French Academy of sciences<ref name=":0" />
[[Category:1949 births]]
[[Category:French biologists]]
[[Category:Molecular biologists]]
[[Category:Paris Descartes University]]
[[Category:Mitochondria]]
[[Category:Mitochondrial diseases]]
[[Category:Mitochondrial proteins]]
[[Category:Members of the French Academy of Sciences]]
[[Category:WikiProject France articles]]
[[Category:WikiProject Europe articles]]
[[Category:French biochemists]]
== Biography ==
Daniel Ricquier, is a university professor and exceptional class hospital practitioner at faculté́ of medicine at the University of Paris-Descartes and at the [[Necker-Enfants Malades Hospital|Necker-Enfants malades Hospital]]<ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> since 2003.
He directed the "Centre de recherche sur l'endocrinologie moléculaire et le développement" of the [[French National Centre for Scientific Research|CNRS]] in Meudon from 1997 to 2002, then the CNRS unit "Biologie des Transporteurs mitochondriaux et métabolisme" from 2002 to 2008 at faculté́ de médecine Necker Paris Descartes and at the Institut de recherches Necker-Enfants Malades. He was Head of the Metabolic Biochemistry Department at Necker Enfants Malades Hospital and at AP-HP from 2003 to 2014. He was elected a member of the Academy of Sciences on 19 November 2002<ref name=":0" />.
== Scientific Works ==
Daniel Ricquier specializes in the [[physiology]] and biochemistry of mitochondria, [[adipose tissue]] and [[Thermogenics|thermogenic]] mechanisms. He is an expert on [[brown adipose tissue]]. His work has contribué́ to identify a family of proteins involved in mitochondrial respiration, [[ATP]] yield, heat production and mitochondrial control of the level of cellular oxygenated [[free radicals]].
Daniel Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes<ref><abbr>(en)</abbr> Ricquier D., Kader J.C, « Mitochondrial protein alteration in active brown fat. A sodium dodecyl sulfate- polyacrylamide gel electrophoretic study », ''Biochem. Biophys'', 1976</ref>, later named UCP ([[uncoupling protein]]) and identified by David Nicholls as the protein responsible for [[heat energy]] dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in [[neonates]] and adult patients and demonstrated that the [[sympathetic nervous system]] controls the development of brown adipose tissue and the synthesis of DCS in animals and humans<ref><abbr>(en)</abbr> Ricquier D., Néchad M., Mory G, « Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma », ''J. Clin. Endocrinol. Metab'', 1982, <abbr>p.</abbr> 805 - 807</ref>. With Fréderic Bouillaud, in 1984 and in collaboration with [[Jean Weissenbach]] at the [[Pasteur Institute]], he isolated and sequenced the complementary [[DNA]] of the UCP and the UCP gene from rodents and humans<ref><abbr>(en)</abbr> Bouillaud F., Ricquier D., Thibault J., Weissenbach J., « Molecular approach to thermogenesis in brown adipose tissue : cDNA cloning of the mitochondrial uncoupling protein », ''Proc. Natl. Acad. Sci. USA'', 1985, <abbr>p.</abbr> 445 - 448</ref>. He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein<ref><abbr>(en)</abbr> Cassard-Doulcier A-M., Gelly C., Fox N., Schrementi J., Raimbault S., Klaus S., Forest C., Bouillaud F., Ricquier D., « Tissue-specific and ß-adrenergic regulation of the mitochondrial uncoupling protein gene - Control by cis-acting elements in the 5'-flanking region. », ''Mol. Endocrinol'', 1993, <abbr>p.</abbr> 497-506</ref> <ref><abbr>(en)</abbr> Miroux B., Frossart V., Raimbault S., Ricquier D., Bouillaud F., « The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins », ''EMBO J. 12'', 1993, <abbr>p.</abbr> 3739-3745</ref> <ref><abbr>(en)</abbr> Bouillaud F., Arechaga I., Petit P.X., Lévi-Meyrueis C., Casteilla L., Laurent M., Rial E., Ricquier D., « A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of the proton transport through the mitochondrial uncoupling protein », ''EMBO J 13'', 1994, <abbr>p.</abbr> 1990-1997</ref>.
Daniel Ricquier identified and characterized in 1997 a second UCP protein called UCP2<ref name=":1"><abbr>(en)</abbr> Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Lévi- Meyrueis C., Bouillaud F., Seldin MF, Surwit RS, Ricquier D., Warden CH., « Uncoupling Protein-2 : a new thermogenic protein and a new gene linked to obesity and hyperinsulism », ''Nature Genetics 15'', 1997, <abbr>p.</abbr> 269-272</ref>, the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP<ref>D. Sanchis, C. Fleury, N. Chomiki et M. Goubern, « BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 273, <abbr>n<sup>o</sup></abbr> 51, 18 décembre 1998, <abbr>p.</abbr> 34611–34615 <small>(ISSN 0021-9258, <nowiki>PMID 9852133</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref> , an avian UCP<ref>S. Raimbault, S. Dridi, F. Denjean et J. Lachuer, « An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds », ''The Biochemical Journal'', <abbr>vol.</abbr> 353, <abbr>n<sup>o</sup></abbr> Pt 3, <abbr>1<sup>er</sup></abbr> février 2001, <abbr>p.</abbr> 441–444 <small>(ISSN 0264-6021, <nowiki>PMID 11171038</nowiki>, PMCID PMC1221587, lire en ligne, consulté le 21 juillet 2017)</small></ref> and a renal mitochondrial transporter KMCP<ref>Anne Haguenauer, Serge Raimbault, Sandrine Masscheleyn et Maria del Mar Gonzalez-Barroso, « A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 280, <abbr>n<sup>o</sup></abbr> 23, 10 juin 2005, <abbr>p.</abbr> 22036–22043 <small>(ISSN 0021-9258, <nowiki>PMID 15809292</nowiki>, DOI 10.1074/jbc.M412136200, lire en ligne, consulté le 21 juillet 2017)</small></ref> and contributed to the identification of the first plant UCP protein<ref><abbr>(en)</abbr> Laloi M., Klein M., Resmeier J.W., Fleury C, Bouillaud F., Ricquier D., « A plant cold-induced uncoupling protein », ''Nature 389'', 1997, <abbr>p.</abbr> 135-136</ref>. He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels<ref>D. Arsenijevic, H. Onuma, C. Pecqueur et S. Raimbault, « Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production », ''Nature Genetics'', <abbr>vol.</abbr> 26, <abbr>n<sup>o</sup></abbr> 4, décembre 2000, <abbr>p.</abbr> 435–439 <small>(ISSN 1061-4036, <nowiki>PMID 11101840</nowiki>, DOI 10.1038/82565, lire en ligne, consulté le 21 juillet 2017)</small></ref> <ref>Marie-Clotilde Alves-Guerra, Sophie Rousset, Claire Pecqueur et Ziad Mallat, « Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation », ''The Journal of Biological Chemistry'', <abbr>vol.</abbr> 278, <abbr>n<sup>o</sup></abbr> 43, 24 octobre 2003, <abbr>p.</abbr> 42307–42312 <small>(ISSN 0021-9258, <nowiki>PMID 12907675</nowiki>, DOI 10.1074/jbc.M306951200, lire en ligne, consulté le 21 juillet 2017)</small></ref> <ref>Yalin Emre, Corinne Hurtaud, Tobias Nübel et François Criscuolo, « Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages », ''The Biochemical Journal'', <abbr>vol.</abbr> 402, <abbr>n<sup>o</sup></abbr> 2, <abbr>1<sup>er</sup></abbr> mars 2007, <abbr>p.</abbr> 271–278 <small>(ISSN 1470-8728, <nowiki>PMID 17073824</nowiki>, PMCID PMC1798432, DOI 10.1042/BJ20061430, lire en ligne, consulté le 21 juillet 2017)</small></ref> , particularly in macrophages in collaboration with Denis Richard at [[Université Laval|Laval University]]. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis<ref>J. Blanc, M. C. Alves-Guerra, B. Esposito et S. Rousset, « Protective role of uncoupling protein 2 in atherosclerosis », ''Circulation'', <abbr>vol.</abbr> 107, <abbr>n<sup>o</sup></abbr> 3, 28 janvier 2003, <abbr>p.</abbr> 388–390 <small>(ISSN 1524-4539, <nowiki>PMID 12551860</nowiki>, lire en ligne, consulté le 21 juillet 2017)</small></ref>.
Daniel Ricquier has demonstrated that mutations in the UCP2 protein induce congenital [[hyperinsulinism]] in children at birth<ref>M. Mar González-Barroso, Irina Giurgea, Fredéric Bouillaud et Andrea Anedda, « Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion », ''PloS One'', <abbr>vol.</abbr> 3, <abbr>n<sup>o</sup></abbr> 12, 2008, e3850 <small>(ISSN 1932-6203, <nowiki>PMID 19065272</nowiki>, PMCID PMC2588657, DOI 10.1371/journal.pone.0003850, lire en ligne, consulté le 21 juillet 2017)</small></ref>. He also described a protective role for UCP2 against autoimmune diabetes<ref>Yalin Emre, Corinne Hurtaud, Melis Karaca et Tobias Nubel, « Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes », ''Proceedings of the National Academy of Sciences of the United States of America'', <abbr>vol.</abbr> 104, <abbr>n<sup>o</sup></abbr> 48, 27 novembre 2007, <abbr>p.</abbr> 19085–19090 <small>(ISSN 1091-6490, <nowiki>PMID 18006654</nowiki>, PMCID PMC2141912, DOI 10.1073/pnas.0709557104, lire en ligne, consulté le 21 juillet 2017)</small></ref>. Applications of the work include metabolic diseases (obesity, diabetes), nutrition, [[Degenerative disease|degenerative diseases]] and [[Autoimmune disease|autoimmune diseases]] involving oxygenated free radicals in [[atherosclerosis]] and [[neurodegeneration]].
== Honours and Awards ==
* 1988: Paul Langevin Prize from the French Academy of sciences
* 1989: [[CNRS Silver Medal|CNRS silver medal]]
* 1995: F. Wasserman Medal of the European Association for the Study of Obesity<ref></ref>
* 2000: Grand Prix des industries agro-alimentaires from the French Academy of sciences
* 2002: Member of the French Academy of sciences<ref name=":0" />
* 2002: Wertheimer Medal from the International Association of Study on Obesity
* 2013: Chevalier in the Ordre de la Légion d'Honneur<ref><small>Décret du 29 mars 2013 portant promotion et nomination</small></ref>
* 2012-2017: Deputy Vice-President for International Relations of the French Academy of sciences<ref name=":0" />
[[Category:1949 births]]
[[Category:French biologists]]
[[Category:Molecular biologists]]
[[Category:Paris Descartes University]]
[[Category:Mitochondria]]
[[Category:Mitochondrial diseases]]
[[Category:Mitochondrial proteins]]
[[Category:Members of the French Academy of Sciences]]
[[Category:WikiProject France articles]]
[[Category:WikiProject Europe articles]]
[[Category:French biochemists]]
December 10, 2019 at 05:17PM
