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Christine Jacobs-Wagner
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Christine Jacobs-Wagner is a [[Microorganism|microbial]] [[Molecular biology|molecular biologist.]] She is the William H. Fleming, MD Professor of Molecular , Cellular, and Developmental Biology at [[Yale University]] and Professor of Microbial Pathogenesis, HHMI investigator, and Director of the Microbial Sciences Institute at [[Yale School of Medicine|Yale Medical School]].<ref>Liquid error: wrong number of arguments (1 for 2)</ref> Jacobs-Wagner's research has shown that bacterial cells have a great deal of substructure including analogs of [[Microfilament|microfilaments]], and that proteins are directed by regulatory processes to locate to specific places within the bacterial cell.<ref name=":1">Liquid error: wrong number of arguments (1 for 2)</ref> She was elected to the [[National Academy of Sciences]] in 2015<ref>Liquid error: wrong number of arguments (1 for 2)</ref> and has received a number of scientific awards.
=== '''Early life and education''' ===
Christine Jacobs-Wagner grew up in [[Belgium]] in a town near [[Liège|Liege]].<ref name=":1" /> She thought of becoming a [[Cycling|cyclist]]<ref name=":1" /> or a [[badminton]] Olympian,<ref></ref> but was undecided about a career through high school.<ref name=":1" /> Christine Jacobs-Wagner received her BS degree in [[biochemistry]] from [[University of Liège|University of Liege]].<ref name=":0">Liquid error: wrong number of arguments (1 for 2)</ref> She also received her MS in 1991 and the PhD in 1996 from University of Liege in Belgium in the field of Biochemistry.<ref name=":2">Liquid error: wrong number of arguments (1 for 2)</ref> She then went to work with [[Lucy Shapiro]] at [[Stanford University School of Medicine|Stanford Medical School]] on a fellowship from the [[European Molecular Biology Organization|European molecular Biology Organization]]. where she studied ''[[Caulobacter crescentus|Caulobacter]]'', a bacterium with a [[flagellum]] on one end and a stalk on the other end, beginning her fascination with how bacterial cells can become [[Asymmetry|asymmetrical]].<ref name=":1" /> From 2004 to 2013, she did research in [[Newcastle upon Tyne]] in the United Kingdom.<ref name=":2" /> <ref name=":0" />
=== '''Academic career''' ===
As of 2018, Jacobs-Wagner holds an endowed chair in Yale Medical School and is director of their Microbial Institute.<ref name=":1" /><ref name=":2" />
=== '''Research''' ===
Christine Jacobs-Wagner's major breakthrough has been the discovery that the tiny cells of bacteria such as ''Caulobacter,'' ''[[Escherichia coli]]'', and ''[[Borrelia]]'' are not simply bags of biochemicals but instead program the locations of their protein components via their regulatory systems.<ref name=":1" /> She also discovered the protein [[crescentin]] which forms bacterial [[Intermediate filament|intermediate filaments]], structures once thought to occur only in [[Eukaryote|eukaryotic]] cells.<ref name=":1" /> The current focus of her laboratory's work is to discover regulation of the times and places for critical components of the [[DNA replication]] and [[cell division]] processes so that proliferation control can be understood.<ref name=":1" />
=== '''Awards & Recognition''' ===
* National Academy of Sciences (2015)<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
* [[Eli Lilly Award in Biological Chemistry|Eli Lilly Award]] American Society of Microbiology (2011)<ref name=":0" />
* WALS lecture [[National Institutes of Health|National Institute of Health]] (2009)<ref name=":0" />
* [[Elizabeth McCoy (microbiologist)|Elizabeth McCoy]] Lecture<ref name=":0" />
* Finalist, Blatvanik Award for Young Scientists [[New York Academy of Sciences]] (2008)<ref name=":0" />
* Women in Cell Biology [[WICB Junior and Senior Awards|WICB Junior and Senior Award]] by [[American Society for Cell Biology|American Society of Cell Biology]] (2007)<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
* Pew Scholarship Award in the Biomedical Sciences [[The Pew Charitable Trusts|PEW Charitable Trust]] (2003)<ref name=":0" />
* Grand Prize Winner of the Young Scientist Award GE & Science (1997)<ref name=":0" />
=== Selected Works ===
MT Cabeen, C Jacobs-Wagner 2005 "Bacterial Cell Shape" ''Nature Reviews Microbiology'' '''3''' (8):601-610.
O. Sliusarenko, J Heinritz, T Emonet, and C Jacobs-Wagner 2011 "High-throughput, suppixel precision analysis of bacterial morphogenesis and spatio-temporal dynamics." M''olecular Microbiology'' '''80''' (3):612-627.
N Ausmees, JR Kuhn, and C Jacobs-Wagner (2003) "The bacterial cytoskeleton: an intermediate filament-like function in cell shape" ''Cell'' '''115''' (6): 705-713.
PM Llopis, AF Jackson, O Sliusarenko, I Surovtsev, J Heinritz, T Emonet…C Jacobs-Wagner (2010) "Spatial organization of the flow of genetic information in bacteria" ''Nature'' '''466''' (7302):77-81.
G Laloux and C Jacobs-Wagner (2014) "How do bacteria localize proteins to the cell pole? ''J Cell Science'' 127: 11-19. doi:10.1242/jcs.138328
M Cabeen and C Jacobs-Wagner (2010) "The bacterial cytoskeleton" ''Annu Rev Genetics'' '''44''': 365-382.
=== '''References''' ===
<references />
[[Category:Women scientists]]
[[Category:Microbiologists]]
[[Category:Yale University faculty]]
[[Category:Biochemists]]
[[Category:Women]]
=== '''Early life and education''' ===
Christine Jacobs-Wagner grew up in [[Belgium]] in a town near [[Liège|Liege]].<ref name=":1" /> She thought of becoming a [[Cycling|cyclist]]<ref name=":1" /> or a [[badminton]] Olympian,<ref></ref> but was undecided about a career through high school.<ref name=":1" /> Christine Jacobs-Wagner received her BS degree in [[biochemistry]] from [[University of Liège|University of Liege]].<ref name=":0">Liquid error: wrong number of arguments (1 for 2)</ref> She also received her MS in 1991 and the PhD in 1996 from University of Liege in Belgium in the field of Biochemistry.<ref name=":2">Liquid error: wrong number of arguments (1 for 2)</ref> She then went to work with [[Lucy Shapiro]] at [[Stanford University School of Medicine|Stanford Medical School]] on a fellowship from the [[European Molecular Biology Organization|European molecular Biology Organization]]. where she studied ''[[Caulobacter crescentus|Caulobacter]]'', a bacterium with a [[flagellum]] on one end and a stalk on the other end, beginning her fascination with how bacterial cells can become [[Asymmetry|asymmetrical]].<ref name=":1" /> From 2004 to 2013, she did research in [[Newcastle upon Tyne]] in the United Kingdom.<ref name=":2" /> <ref name=":0" />
=== '''Academic career''' ===
As of 2018, Jacobs-Wagner holds an endowed chair in Yale Medical School and is director of their Microbial Institute.<ref name=":1" /><ref name=":2" />
=== '''Research''' ===
Christine Jacobs-Wagner's major breakthrough has been the discovery that the tiny cells of bacteria such as ''Caulobacter,'' ''[[Escherichia coli]]'', and ''[[Borrelia]]'' are not simply bags of biochemicals but instead program the locations of their protein components via their regulatory systems.<ref name=":1" /> She also discovered the protein [[crescentin]] which forms bacterial [[Intermediate filament|intermediate filaments]], structures once thought to occur only in [[Eukaryote|eukaryotic]] cells.<ref name=":1" /> The current focus of her laboratory's work is to discover regulation of the times and places for critical components of the [[DNA replication]] and [[cell division]] processes so that proliferation control can be understood.<ref name=":1" />
=== '''Awards & Recognition''' ===
* National Academy of Sciences (2015)<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
* [[Eli Lilly Award in Biological Chemistry|Eli Lilly Award]] American Society of Microbiology (2011)<ref name=":0" />
* WALS lecture [[National Institutes of Health|National Institute of Health]] (2009)<ref name=":0" />
* [[Elizabeth McCoy (microbiologist)|Elizabeth McCoy]] Lecture<ref name=":0" />
* Finalist, Blatvanik Award for Young Scientists [[New York Academy of Sciences]] (2008)<ref name=":0" />
* Women in Cell Biology [[WICB Junior and Senior Awards|WICB Junior and Senior Award]] by [[American Society for Cell Biology|American Society of Cell Biology]] (2007)<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
* Pew Scholarship Award in the Biomedical Sciences [[The Pew Charitable Trusts|PEW Charitable Trust]] (2003)<ref name=":0" />
* Grand Prize Winner of the Young Scientist Award GE & Science (1997)<ref name=":0" />
=== Selected Works ===
MT Cabeen, C Jacobs-Wagner 2005 "Bacterial Cell Shape" ''Nature Reviews Microbiology'' '''3''' (8):601-610.
O. Sliusarenko, J Heinritz, T Emonet, and C Jacobs-Wagner 2011 "High-throughput, suppixel precision analysis of bacterial morphogenesis and spatio-temporal dynamics." M''olecular Microbiology'' '''80''' (3):612-627.
N Ausmees, JR Kuhn, and C Jacobs-Wagner (2003) "The bacterial cytoskeleton: an intermediate filament-like function in cell shape" ''Cell'' '''115''' (6): 705-713.
PM Llopis, AF Jackson, O Sliusarenko, I Surovtsev, J Heinritz, T Emonet…C Jacobs-Wagner (2010) "Spatial organization of the flow of genetic information in bacteria" ''Nature'' '''466''' (7302):77-81.
G Laloux and C Jacobs-Wagner (2014) "How do bacteria localize proteins to the cell pole? ''J Cell Science'' 127: 11-19. doi:10.1242/jcs.138328
M Cabeen and C Jacobs-Wagner (2010) "The bacterial cytoskeleton" ''Annu Rev Genetics'' '''44''': 365-382.
=== '''References''' ===
<references />
[[Category:Women scientists]]
[[Category:Microbiologists]]
[[Category:Yale University faculty]]
[[Category:Biochemists]]
[[Category:Women]]
October 23, 2018 at 03:10AM
