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Regeneration Next Initiative
RegenerationBiology: New Page about an Initiative at Duke University working on Regenerative Medicine
== Regeneration Next Initiative ==
The [https://ift.tt/2za0JXC Regeneration Next Initiative] (RNI) was established in 2016 to advance discovery and applications in the field of [[Regeneration (biology)|regenerative biology]] and [[medicine]] at [[Duke University]], with the ultimate goal of identifying new therapies.
=== About ===
[[Regenerative medicine]] seeks to replace lost, damaged or diseased tissue with new, healthy tissue through procedures not requiring organ donation and transplantation. For example, bone marrow replacement, a procedure that eliminates the sources of diseased hematopoietic cells and substitutes a healthy system, is based on the activity of a small number of transplanted stem cells.
However, regenerative therapies have not been developed for most [[Organ system|organ systems]], including the [[brain]], [[heart]], [[kidney]], [[pancreas]], and [[Joint|joints]].
While strategies in the past decade have focused on potential therapies involving treatment with cell populations, tapping into natural regeneration programs and boosting the endogenous capacity of tissue to regenerate or rejuvenate is a prerogative for the field today. This is where the discovery science of [[Developmental biology|developmental]] and [[Regeneration (biology)|regeneration biology]] and the application of regenerative medicine must meet and work together closely.
=== Directors ===
* [https://ift.tt/2OYJ1kf Kenneth D. Poss], Director
* [[Benjamin Alman|Benjamin A. Alman]], Co-Director
* [https://ift.tt/2qOKKNi Nenad Bursac], Co-Director
* [https://ift.tt/2KJ5nlC Cagla Eroglu], Co-Director
* [https://ift.tt/31NRLeM David R. Sherwood], Co-Director
=== Current faculty members, with primary departmental affiliation ===
* [[Benjamin Alman|Benjamin A. Alman]], M.D. – Orthopaedic Surgery
* [https://ift.tt/2KFUDoa Aravind Asokan], Ph.D. – Surgical Sciences
* [https://ift.tt/31P2V2M Michel Bagnat], Ph.D. – Cell Biology
* [https://ift.tt/2KFUG3k Gurpreet Baht], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31Ng6Bl Christina E. Barkauskas], M.D. – Paulmonary, Allergy, and Critical Care Medicine
* [https://ift.tt/2KGbQxO L. Ryan Baugh], Ph.D. – Biology
* [https://ift.tt/31KLEaU Philip N. Benfey], Ph.D. – Biology
* [https://ift.tt/2KFUH7o Anne F. Buckley], M.D./Ph.D. – Pathology
* [https://ift.tt/2qOKKNi Nenad Bursac], Ph.D. – Biomedical Engineering
* [https://ift.tt/31Ng8cr Blanche Capel], Ph.D. – Cell Biology
* [https://ift.tt/2KFUIZ0 Marc G. Caron], Ph.D. – Cell Biology
* [https://ift.tt/31Ng9Nx Romain Cartoni], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KFUKA6 Nelson Jen An Chao], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/31Ngakz Louis E. DeFrate], Sc.D. – Orthopaedic Surgery
* [https://ift.tt/2KFUMbc Stefano Di Talia], Ph.D. – Cell Biology
* [https://ift.tt/2P4jmXK Yarui Diao], Ph.D. – Cell Biology
* [https://ift.tt/31KLErq Anna Mae Diehl], M.D. – Gastroenterology
* [https://ift.tt/2KFUNfg Phuong Linh Doan], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KJ5nlC Cagla Eroglu], Ph.D. – Cell Biology
* [https://ift.tt/31LQMvy Donald T. Fox], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KIPYBZ Katherine S. Garman], M.D. – Gastroenterology
* [https://ift.tt/2mJaTaC Charles Gersbach], Ph.D. – Biomedical Engineering
* [https://ift.tt/2KL20uR Sarah C. Goetz], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/31SYkwL Ronald N. Goldberg], M.D. – Pediatrics
* [https://ift.tt/2KFUXDo Alexander Grabner], M.D. – Nephrology
* [https://ift.tt/31NggIX Matthew J. Hilton], Ph.D. – Orthopaedic Surgery
* [[Brigid Hogan|Brigid L. M. Hogan]], Ph.D. – Cell Biology
* [https://ift.tt/2KIbSFz Hans-Ewald Hohmeier], M.D./Ph.D. – Endocrinology, Metabolism, and Nutrition
* [https://ift.tt/31NghN1 Mitchell E. Horowitz], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KJH2wk Kim M. Huffman], M.D./Ph.D. – Rheumatology and Immunology
* [https://ift.tt/31Q2MfK Courtney M. Karner], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KFURvw Ravi Karra], M.D. – Cardiology
* [https://ift.tt/31OCs5o Jeremy N. Kay], Ph.D. – Neurobiology
* [https://ift.tt/2KFUS2y Daniel P. Kiehart], Ph.D. – Biology
* [https://ift.tt/31LWqhl David G. Kirsch], M.D./Ph.D. – Radiation Oncology
* [https://ift.tt/2KFUT6C Virginia Kraus], M.D./Ph.D. – Rheumatology and Immunology
* [https://ift.tt/31MU81j Chay T. Kuo], M.D./Ph.D. – Cell Biology
* [[Joanne Kurtzberg]], M.D. – Pediatrics
* [https://ift.tt/2KFqO7k Albert R. La Spada], M.D./Ph.D. – Neurology
* [https://ift.tt/31O5u59 Terry H. Lechler], Ph.D. – Dermatology
* [https://ift.tt/2KIfBCR Chuan-Yuan Li], Sc.D. – Dermatology
* [https://ift.tt/31NgnnR Herbert K. Lyerly], M.D. – Surgical Sciences
* [https://ift.tt/2KFUW2i Amanda S. MacLeod], Ph.D. – Dermatology
* [https://ift.tt/31IAovM Bernard Mathey-Prevot], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KGC9UK David R. McClay, Jr.], Ph.D. – Biology
* [https://ift.tt/31NRN6o Amy McNulty], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KKpMHk Samira Musah], Ph.D. – Biomedical Engineering
* [https://ift.tt/31P2Zzy Steven A. Olson], M.D. – Orthopaedic Surgery
* [https://ift.tt/2KIYgdd Mark Onaitis], M.D./M.H.S. – Cardiovascular and Thoracic Surgery
* [https://ift.tt/31RSg7M Jatin Roper], M.D. – Gastroenterology
* [https://ift.tt/2KIbTcB Tatiana Segura], Ph.D. – Biomedical Engineering
* [https://ift.tt/31SD4qD Thorsten M. Seyler], M.D./Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KIbUNH Xiling Shen], Ph.D. – Biomedical Engineering
* [https://ift.tt/31QR1W2 David R. Sherwood], Ph.D. – Biology
* [https://ift.tt/2jwAJ2i Debra L. Silver], Ph.D. – Molecular Genetics and Microbiology
* [https://ift.tt/31Z1AXx Dorothy A. Sipkins], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KIfC9T Tomokazu Souma], M.D./Ph.D. – Nephrology
* [https://ift.tt/31RSfke Purushothama Rao Tata], Ph.D. – Cell Biology
* [[George Truskey|George A. Truskey]], Ph.D. – Biomedical Engineering
* [https://ift.tt/2PppRiC Shyni Varghese], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31OCAlo Fan Wang], Ph.D. – Neurobiology
* [https://ift.tt/2KGCabg Jennifer L. West], Ph.D. – Biomedical Engineering
* [https://ift.tt/31Q7WYZ James P. White, Jr.], Ph.D. – Hematology
* [https://ift.tt/2KJVuEB Colleen Wu], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31H8hNE Dong Yan], Ph.D. – Molecular Genetics and Microbiology
* [https://ift.tt/2KGSrg5 Eda Yildrim], Ph.D. – Cell Biology
* [https://ift.tt/31N66bl Henry Yin], Ph.D. – Psychology and Neuroscience
* [https://ift.tt/2KL211T Zhao Zhang], Ph.D. – Pharmacology and Cancer Biology
=== Postdoctoral fellowship recipients, with affiliations ===
· Louis-Jan Pilaz, Ph.D. – Molecular Genetics and Microbiology (Silver Lab)
· Ryan Schweller, Ph.D. – Biomedical Engineering (West Lab)
· Jessica Sawyer, Ph.D. – Pharmacology and Cancer Biology (Fox Lab)
· Sehwon Koh, Ph.D. – Cell Biology (Eroglu Lab)
· Brian Cosgrove, Ph.D. – Biomedical Engineering (Gersbach Lab)
· WenXiu Ning, Ph.D. – Dermatology (Lechler Lab)
· Abdelhalim Loukil, Ph.D. – Pharmacology and Cancer Biology (Goetz Lab)
· Valentina Cigliola, Ph.D. – Cell Biology (Poss Lab)
· Francesco Paolo Ulloa Severino, Ph.D. – Cell Biology (Eroglu Lab)
· Jeongeun Hyun, Ph.D. – Gastroenterlogy (Diehl Lab)
· Guoli Hu, Ph.D. – Orthopaedic Surgery (Karner Lab)
· Mariah Hoye, Ph.D. – Molecular Genetics and Microbiology (Silver Lab)
· Gabriel Butterfield, Ph.D. – Biomedical Engineering (Gersbach Lab)
· Juhi Samal, Ph.D. – Biomedical Engineering (Segura Lab)
· Vishwaraj Sontake, Ph.D. – Cell Biology (Tata Lab)
· Yu Xiang, Ph.D. – Cell Biology (Diao Lab)
=== Selected Publications ===
* [https://ift.tt/31SD6Ph Sakers K, Eroglu C.Control of neural development and function by glial neuroligins.Curr Opin Neurobiol. 2019 Aug;57:163-170. doi: 10.1016/j.conb.2019.03.007. Epub 2019 Apr 13. Review.]
* [https://ift.tt/2KIviKA Cohen E, Allen SR, Sawyer JK, Fox DT. Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.Elife. 2018 Aug 17;7. pii: e38327. doi: 10.7554/eLife.38327.]
* [https://ift.tt/31N66In Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.]
* [https://ift.tt/2KGCcjo Jayadev R, Chi Q, Keeley DP, Hastie EL, Kelley LC, Sherwood DR. α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes.J Cell Biol. 2019 Aug 6. pii: jcb.201903124. doi: 10.1083/jcb.201903124.]
* [https://ift.tt/31N66YT Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM. Dysregulated activation of fetal liver programme in acute liver failure. Gut. 2019 Jun;68(6):1076-1087. doi: 10.1136/gutjnl-2018-317603. Epub 2019 Jan 22.]
* [https://ift.tt/2KFWIR3 Han Y, Chen A, Umansky KB, Oonk KA, Choi WY, Dickson AL, Ou J, Cigliola V, Yifa O, Cao J, Tornini VA, Cox BD, Tzahor E, Poss KD. Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Dev Cell. 2019 Mar 25;48(6):853-863.e5. doi: 10.1016/j.devcel.2019.01.001. Epub 2019 Jan 31.]
* [https://ift.tt/31QR306 Kelley LC, Chi Q, Cáceres R, Hastie E, Schindler AJ, Jiang Y, Matus DQ, Plastino J, Sherwood DR. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. Dev Cell. 2019 Feb 11;48(3):313-328.e8. doi: 10.1016/j.devcel.2018.12.018. Epub 2019 Jan 24.]
* [https://ift.tt/2KGCeYy Gordon KL, Payne SG, Linden-High LM, Pani AM, Goldstein B, Hubbard EJA, Sherwood DR. Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle. Curr Biol. 2019 Mar 4;29(5):823-833.e5. doi: 10.1016/j.cub.2019.01.056. Epub 2019 Feb 21.]
* [https://ift.tt/31TYvYF Katsura H, Kobayashi Y, Tata PR, Hogan BLM. IL-1and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019 Apr 9;12(4):657-666. doi: 10.1016/j.stemcr.2019.02.013. Epub 2019 Mar 28.]
* [https://ift.tt/2KJVuV7 Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 May;569(7757):570-575. doi: 10.1038/s41586-019-1150-2. Epub 2019 Apr 24.]
* [https://ift.tt/31RSfRg <nowiki>Hartman JH, Richie CT, Gordon KL, Mello DF, Castillo P, Zhu A, Wang Y, Hoffer BJ, Sherwood DR, Meyer JN, Harvey BK. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. Eur J Cell Biol. 2019 May 21. pii: S0171-9335(18)30348-0. doi: 10.1016/j.ejcb.2019.05.002. [Epub ahead of print]</nowiki>]
* [https://ift.tt/2KK89at Kwak YH, Barrientos T, Furman B, Zhang H, Puviindran V, Cutcliffe H, Herfarth J, Nwankwo E, Alman BA. Pharmacologic targeting of β-catenin improves fracture healing in old mice. Sci Rep. 2019 Jun 21;9(1):9005. doi: 10.1038/s41598-019-45339-0.]
* [https://ift.tt/31Z1Buz E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron. 2018 Jan 3;97(1):125-138.e5. doi: 10.1016/j.neuron.2017.12.001.]
* [https://ift.tt/2KHZBRo Sherwood DR, Plastino J. Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo.Genetics. 2018 Jan;208(1):53-78. doi: 10.1534/genetics.117.300082. Review.]
* [https://ift.tt/31O5vpJ Koh S, Chen WJ, Dejneka NS, Harris IR, Lu B, Girman S, Saylor J, Wang S, Eroglu C. Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity. J Neurosci. 2018 Mar 21;38(12):2923-2943. doi: 10.1523/JNEUROSCI.1532-17.2018. Epub 2018 Feb 5.]
* [https://ift.tt/2KGCkiS Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA. Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051.]
* [https://ift.tt/31Q7XMx Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, Bagnat M. Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Rep.2018 Feb 20;22(8):2026-2038. doi: 10.1016/j.celrep.2018.01.084.]
* [https://ift.tt/2KIvj16 Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 Mar 26;44(6):679-693.e5. doi: 10.1016/j.devcel.2018.02.024.]
* [https://ift.tt/31NgrUD Tata A, Kobayashi Y, Chow RD, Tran J, Desai A, Massri AJ, McCord TJ, Gunn MD, Tata PR. Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. Cell Stem Cell. 2018 May 3;22(5):668-683.e6. doi: 10.1016/j.stem.2018.03.018. Epub 2018 Apr 12.]
* [https://ift.tt/2KGClTY Kobayashi Y, Tata PR. Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung. Dev Cell. 2018 May 21;45(4):425-426. doi: 10.1016/j.devcel.2018.05.009.]
* [https://ift.tt/31UEfWV Keeley DP, Sherwood DR. Tissue linkage through adjoining basement membranes: The long and the short term of it. Matrix Biol. 2019 Jan;75-76:58-71. doi: 10.1016/j.matbio.2018.05.009. Epub 2018 May 24. Review.]
* [https://ift.tt/31N66In Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA. Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.]
* [https://ift.tt/2KHdY8q Atik AF, Suryadevara CM, Schweller RM, West JL, Healy P, Herndon li JE, Congdon KL, Sanchez-Perez L, McLendon RE, Archer GE, Fecci P, Sampson JH. Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells. J Clin Neurosci.2018 Oct;56:163-168. doi: 10.1016/j.jocn.2018.06.005. Epub 2018 Jul 21.]
* [https://ift.tt/31TYy6N Cao J, Poss KD. The epicardium as a hub for heart regeneration. Nat Rev Cardiol. 2018 Oct;15(10):631-647. doi: 10.1038/s41569-018-0046-4. Review.]
* [https://ift.tt/2KGC8jq Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1.]
* [https://ift.tt/31TYzaR Karra R, Foglia MJ, Choi WY, Belliveau C, DeBenedittis P, Poss KD. Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8805-8810. doi: 10.1073/pnas.1722594115. Epub 2018 Aug 13.]
* [https://ift.tt/2KIbVRL Walton EM, Cronan MR, Cambier CJ, Rossi A, Marass M, Foglia MD, Brewer WJ, Poss KD, Stainier DYR, Bertozzi CR, Tobin DM. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host Microbe. 2018 Oct 10;24(4):514-525.e6. doi: 10.1016/j.chom.2018.09.004.]
* [https://ift.tt/31KLGQ4 Cáceres R, Bojanala N, Kelley LC, Dreier J, Manzi J, Di Federico F, Chi Q, Risler T, Testa I, Sherwood DR, Plastino J. Forces drive basement membrane invasion in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11537-11542. doi: 10.1073/pnas.1808760115. Epub 2018 Oct 22.]
* [https://ift.tt/2KGCo26 Mokalled MH, Poss KD. A Regeneration Toolkit. Dev Cell. 2018 Nov 5;47(3):267-280. doi: 10.1016/j.devcel.2018.10.015.]
* [https://ift.tt/31QR3x8 Cox BD, De Simone A, Tornini VA, Singh SP, Di Talia S, Poss KD. In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. Curr Biol. 2018 Dec 17;28(24):3937-3947.e4. doi: 10.1016/j.cub.2018.10.052. Epub 2018 Nov 29.]
* [https://ift.tt/2KGCoz8 Vi L, Baht GS, Soderblom EJ, Whetstone H, Wei Q, Furman B, Puviindran V, Nadesan P, Foster M, Poon R, White JP, Yahara Y, Ng A, Barrientos T, Grynpas M, Mosely MA,Alman BA. Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. Nat Commun. 2018 Dec 5;9(1):5191. doi: 10.1038/s41467-018-07666-0.]
* [https://ift.tt/31NRNTW Fernandez CE, Bakovic M, Karra R. Endothelial Contributions to Zebrafish Heart Regeneration. J Cardiovasc Dev Dis. 2018 Dec 11;5(4). pii: E56. doi: 10.3390/jcdd5040056. Review.]
* [https://ift.tt/2KGCp6a Juhas M, Abutaleb N, Wang JT, Ye J, Shaikh Z, Sriworarat C, Qian Y, Bursac N. Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration. Nat Biomed Eng. 2018 Dec;2(12):942-954. doi: 10.1038/s41551-018-0290-2. Epub 2018 Oct 1.]
* [https://ift.tt/31Q2OnS Goldman JA, Kuzu G, Lee N, Karasik J, Gemberling M, Foglia MJ, Karra R, Dickson AL, Sun F, Tolstorukov MY, Poss KD. Resolving Heart Regeneration by Replacement Histone Profiling. Dev Cell. 2017 Feb 27;40(4):392-404.e5. doi: 10.1016/j.devcel.2017.01.013.]
* [https://ift.tt/2KGCpDc Pilaz LJ, Silver DL. Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells. FEBS Lett. 2017 Jun;591(11):1526-1539. doi: 10.1002/1873-3468.12626. Epub 2017 Apr 6. Review.]
* [https://ift.tt/31N67Mr Li Y, Asfour H, Bursac N. Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25.]
* [https://ift.tt/2KIbZ3X Jayadev R, Sherwood DR. Basement membranes. Curr Biol. 2017 Mar 20;27(6):R207-R211. doi: 10.1016/j.cub.2017.02.006.]
* [https://ift.tt/31TYF2d Schweller RM, Wu ZJ, Klitzman B, West JL. Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. Ann Biomed Eng. 2017 Jun;45(6):1387-1398. doi: 10.1007/s10439-017-1822-8. Epub 2017 Mar 30.]
* [https://ift.tt/2KGCqae Tzahor E, Poss KD. Cardiac regeneration strategies: Staying young at heart. Science. 2017 Jun 9;356(6342):1035-1039. doi: 10.1126/science.aam5894. Epub 2017 Jun 8. Review.]
* [https://ift.tt/31TYFzf Linden LM, Gordon KL, Pani AM, Payne SG, Garde A, Burkholder D, Chi Q, Goldstein B, Sherwood DR. Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. Dev Biol. 2017 Sep 1;429(1):271-284. doi: 10.1016/j.ydbio.2017.06.019. Epub 2017 Jun 23.]
* [https://ift.tt/2KIc0F3 Karra R, Walter AO, Wu SM. The relationship between cardiac endothelium and fibroblasts: it's complicated. J Clin Invest. 2017 Aug 1;127(8):2892-2894. doi: 10.1172/JCI95492. Epub 2017 Jun 26.]
* [https://ift.tt/31TYHHn Tornini VA, Thompson JD, Allen RL, Poss KD. Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. Development. 2017 Aug 15;144(16):2889-2895. doi: 10.1242/dev.155655.]
* [https://ift.tt/2KGCruO Chen CH, Poss KD. Regeneration Genetics. Annu Rev Genet. 2017 Nov 27;51:63-82. doi: 10.1146/annurev-genet-120116-024554. Epub 2017 Aug 30. Review.]
* [https://ift.tt/31TYILr Kelley LC, Wang Z, Hagedorn EJ, Wang L, Shen W, Lei S, Johnson SA, Sherwood DR. Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. Nat Protoc. 2017 Oct;12(10):2081-2096. doi: 10.1038/nprot.2017.093. Epub 2017 Sep 7.]
* [https://ift.tt/2KGCs1Q Jayadev R, Sherwood DR. Morphogenesis: Shaping Tissues through Extracellular Force Gradients. Curr Biol. 2017 Sep 11;27(17):R850-R852. doi: 10.1016/j.cub.2017.07.040.]
* [https://ift.tt/31P30DC Sawyer JK, Cohen E, Fox DT. Interorgan regulation of Drosophilaintestinal stem cell proliferation by a hybrid organ boundary zone.Development. 2017 Nov 15;144(22):4091-4102. doi: 10.1242/dev.153114. Epub 2017 Sep 25.]
* [https://ift.tt/2KGCt5U Cao, J., Wang, J., Jackman, C.P., Cox, A.H., Balowski, J.J., Cox, B.D., De Simone, A., Dickson, A.L., DiTalia, S.,Small, E.M., Kiehart, D.P., Bursac, N., Poss, K.D. Tension Creates Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. Dev Cell. 2017 Sep 25;42(6):600-615.e4. doi: 10.1016/j.devcel.2017.08.024.]
* [https://ift.tt/31TYN1H Naegeli KM, Hastie E, Garde A, Wang Z, Keeley DP, Gordon KL, Pani AM, Kelley LC, Morrissey MA, Chi Q, Goldstein B, Sherwood DR. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Dev Cell. 2017 Nov 20;43(4):403-417.e10. doi: 10.1016/j.devcel.2017.10.024.]
* [https://ift.tt/2KIc2g9 Konkimalla A, Tata PR. Plasticity in Olfactory Epithelium: Is It a Sniffer or Shape Shifter? Cell Stem Cell. 2017 Dec 7;21(6):707-708. doi: 10.1016/j.stem.2017.11.014.]
* [https://ift.tt/31KLHn6 Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 Dec 27;6. pii: e31683. doi: 10.7554/eLife.31683.]
The [https://ift.tt/2za0JXC Regeneration Next Initiative] (RNI) was established in 2016 to advance discovery and applications in the field of [[Regeneration (biology)|regenerative biology]] and [[medicine]] at [[Duke University]], with the ultimate goal of identifying new therapies.
=== About ===
[[Regenerative medicine]] seeks to replace lost, damaged or diseased tissue with new, healthy tissue through procedures not requiring organ donation and transplantation. For example, bone marrow replacement, a procedure that eliminates the sources of diseased hematopoietic cells and substitutes a healthy system, is based on the activity of a small number of transplanted stem cells.
However, regenerative therapies have not been developed for most [[Organ system|organ systems]], including the [[brain]], [[heart]], [[kidney]], [[pancreas]], and [[Joint|joints]].
While strategies in the past decade have focused on potential therapies involving treatment with cell populations, tapping into natural regeneration programs and boosting the endogenous capacity of tissue to regenerate or rejuvenate is a prerogative for the field today. This is where the discovery science of [[Developmental biology|developmental]] and [[Regeneration (biology)|regeneration biology]] and the application of regenerative medicine must meet and work together closely.
=== Directors ===
* [https://ift.tt/2OYJ1kf Kenneth D. Poss], Director
* [[Benjamin Alman|Benjamin A. Alman]], Co-Director
* [https://ift.tt/2qOKKNi Nenad Bursac], Co-Director
* [https://ift.tt/2KJ5nlC Cagla Eroglu], Co-Director
* [https://ift.tt/31NRLeM David R. Sherwood], Co-Director
=== Current faculty members, with primary departmental affiliation ===
* [[Benjamin Alman|Benjamin A. Alman]], M.D. – Orthopaedic Surgery
* [https://ift.tt/2KFUDoa Aravind Asokan], Ph.D. – Surgical Sciences
* [https://ift.tt/31P2V2M Michel Bagnat], Ph.D. – Cell Biology
* [https://ift.tt/2KFUG3k Gurpreet Baht], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31Ng6Bl Christina E. Barkauskas], M.D. – Paulmonary, Allergy, and Critical Care Medicine
* [https://ift.tt/2KGbQxO L. Ryan Baugh], Ph.D. – Biology
* [https://ift.tt/31KLEaU Philip N. Benfey], Ph.D. – Biology
* [https://ift.tt/2KFUH7o Anne F. Buckley], M.D./Ph.D. – Pathology
* [https://ift.tt/2qOKKNi Nenad Bursac], Ph.D. – Biomedical Engineering
* [https://ift.tt/31Ng8cr Blanche Capel], Ph.D. – Cell Biology
* [https://ift.tt/2KFUIZ0 Marc G. Caron], Ph.D. – Cell Biology
* [https://ift.tt/31Ng9Nx Romain Cartoni], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KFUKA6 Nelson Jen An Chao], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/31Ngakz Louis E. DeFrate], Sc.D. – Orthopaedic Surgery
* [https://ift.tt/2KFUMbc Stefano Di Talia], Ph.D. – Cell Biology
* [https://ift.tt/2P4jmXK Yarui Diao], Ph.D. – Cell Biology
* [https://ift.tt/31KLErq Anna Mae Diehl], M.D. – Gastroenterology
* [https://ift.tt/2KFUNfg Phuong Linh Doan], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KJ5nlC Cagla Eroglu], Ph.D. – Cell Biology
* [https://ift.tt/31LQMvy Donald T. Fox], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KIPYBZ Katherine S. Garman], M.D. – Gastroenterology
* [https://ift.tt/2mJaTaC Charles Gersbach], Ph.D. – Biomedical Engineering
* [https://ift.tt/2KL20uR Sarah C. Goetz], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/31SYkwL Ronald N. Goldberg], M.D. – Pediatrics
* [https://ift.tt/2KFUXDo Alexander Grabner], M.D. – Nephrology
* [https://ift.tt/31NggIX Matthew J. Hilton], Ph.D. – Orthopaedic Surgery
* [[Brigid Hogan|Brigid L. M. Hogan]], Ph.D. – Cell Biology
* [https://ift.tt/2KIbSFz Hans-Ewald Hohmeier], M.D./Ph.D. – Endocrinology, Metabolism, and Nutrition
* [https://ift.tt/31NghN1 Mitchell E. Horowitz], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KJH2wk Kim M. Huffman], M.D./Ph.D. – Rheumatology and Immunology
* [https://ift.tt/31Q2MfK Courtney M. Karner], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KFURvw Ravi Karra], M.D. – Cardiology
* [https://ift.tt/31OCs5o Jeremy N. Kay], Ph.D. – Neurobiology
* [https://ift.tt/2KFUS2y Daniel P. Kiehart], Ph.D. – Biology
* [https://ift.tt/31LWqhl David G. Kirsch], M.D./Ph.D. – Radiation Oncology
* [https://ift.tt/2KFUT6C Virginia Kraus], M.D./Ph.D. – Rheumatology and Immunology
* [https://ift.tt/31MU81j Chay T. Kuo], M.D./Ph.D. – Cell Biology
* [[Joanne Kurtzberg]], M.D. – Pediatrics
* [https://ift.tt/2KFqO7k Albert R. La Spada], M.D./Ph.D. – Neurology
* [https://ift.tt/31O5u59 Terry H. Lechler], Ph.D. – Dermatology
* [https://ift.tt/2KIfBCR Chuan-Yuan Li], Sc.D. – Dermatology
* [https://ift.tt/31NgnnR Herbert K. Lyerly], M.D. – Surgical Sciences
* [https://ift.tt/2KFUW2i Amanda S. MacLeod], Ph.D. – Dermatology
* [https://ift.tt/31IAovM Bernard Mathey-Prevot], Ph.D. – Pharmacology and Cancer Biology
* [https://ift.tt/2KGC9UK David R. McClay, Jr.], Ph.D. – Biology
* [https://ift.tt/31NRN6o Amy McNulty], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KKpMHk Samira Musah], Ph.D. – Biomedical Engineering
* [https://ift.tt/31P2Zzy Steven A. Olson], M.D. – Orthopaedic Surgery
* [https://ift.tt/2KIYgdd Mark Onaitis], M.D./M.H.S. – Cardiovascular and Thoracic Surgery
* [https://ift.tt/31RSg7M Jatin Roper], M.D. – Gastroenterology
* [https://ift.tt/2KIbTcB Tatiana Segura], Ph.D. – Biomedical Engineering
* [https://ift.tt/31SD4qD Thorsten M. Seyler], M.D./Ph.D. – Orthopaedic Surgery
* [https://ift.tt/2KIbUNH Xiling Shen], Ph.D. – Biomedical Engineering
* [https://ift.tt/31QR1W2 David R. Sherwood], Ph.D. – Biology
* [https://ift.tt/2jwAJ2i Debra L. Silver], Ph.D. – Molecular Genetics and Microbiology
* [https://ift.tt/31Z1AXx Dorothy A. Sipkins], M.D. – Hematologic Malignancies and Cellular Therapies
* [https://ift.tt/2KIfC9T Tomokazu Souma], M.D./Ph.D. – Nephrology
* [https://ift.tt/31RSfke Purushothama Rao Tata], Ph.D. – Cell Biology
* [[George Truskey|George A. Truskey]], Ph.D. – Biomedical Engineering
* [https://ift.tt/2PppRiC Shyni Varghese], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31OCAlo Fan Wang], Ph.D. – Neurobiology
* [https://ift.tt/2KGCabg Jennifer L. West], Ph.D. – Biomedical Engineering
* [https://ift.tt/31Q7WYZ James P. White, Jr.], Ph.D. – Hematology
* [https://ift.tt/2KJVuEB Colleen Wu], Ph.D. – Orthopaedic Surgery
* [https://ift.tt/31H8hNE Dong Yan], Ph.D. – Molecular Genetics and Microbiology
* [https://ift.tt/2KGSrg5 Eda Yildrim], Ph.D. – Cell Biology
* [https://ift.tt/31N66bl Henry Yin], Ph.D. – Psychology and Neuroscience
* [https://ift.tt/2KL211T Zhao Zhang], Ph.D. – Pharmacology and Cancer Biology
=== Postdoctoral fellowship recipients, with affiliations ===
· Louis-Jan Pilaz, Ph.D. – Molecular Genetics and Microbiology (Silver Lab)
· Ryan Schweller, Ph.D. – Biomedical Engineering (West Lab)
· Jessica Sawyer, Ph.D. – Pharmacology and Cancer Biology (Fox Lab)
· Sehwon Koh, Ph.D. – Cell Biology (Eroglu Lab)
· Brian Cosgrove, Ph.D. – Biomedical Engineering (Gersbach Lab)
· WenXiu Ning, Ph.D. – Dermatology (Lechler Lab)
· Abdelhalim Loukil, Ph.D. – Pharmacology and Cancer Biology (Goetz Lab)
· Valentina Cigliola, Ph.D. – Cell Biology (Poss Lab)
· Francesco Paolo Ulloa Severino, Ph.D. – Cell Biology (Eroglu Lab)
· Jeongeun Hyun, Ph.D. – Gastroenterlogy (Diehl Lab)
· Guoli Hu, Ph.D. – Orthopaedic Surgery (Karner Lab)
· Mariah Hoye, Ph.D. – Molecular Genetics and Microbiology (Silver Lab)
· Gabriel Butterfield, Ph.D. – Biomedical Engineering (Gersbach Lab)
· Juhi Samal, Ph.D. – Biomedical Engineering (Segura Lab)
· Vishwaraj Sontake, Ph.D. – Cell Biology (Tata Lab)
· Yu Xiang, Ph.D. – Cell Biology (Diao Lab)
=== Selected Publications ===
* [https://ift.tt/31SD6Ph Sakers K, Eroglu C.Control of neural development and function by glial neuroligins.Curr Opin Neurobiol. 2019 Aug;57:163-170. doi: 10.1016/j.conb.2019.03.007. Epub 2019 Apr 13. Review.]
* [https://ift.tt/2KIviKA Cohen E, Allen SR, Sawyer JK, Fox DT. Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut.Elife. 2018 Aug 17;7. pii: e38327. doi: 10.7554/eLife.38327.]
* [https://ift.tt/31N66In Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.]
* [https://ift.tt/2KGCcjo Jayadev R, Chi Q, Keeley DP, Hastie EL, Kelley LC, Sherwood DR. α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes.J Cell Biol. 2019 Aug 6. pii: jcb.201903124. doi: 10.1083/jcb.201903124.]
* [https://ift.tt/31N66YT Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM. Dysregulated activation of fetal liver programme in acute liver failure. Gut. 2019 Jun;68(6):1076-1087. doi: 10.1136/gutjnl-2018-317603. Epub 2019 Jan 22.]
* [https://ift.tt/2KFWIR3 Han Y, Chen A, Umansky KB, Oonk KA, Choi WY, Dickson AL, Ou J, Cigliola V, Yifa O, Cao J, Tornini VA, Cox BD, Tzahor E, Poss KD. Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish. Dev Cell. 2019 Mar 25;48(6):853-863.e5. doi: 10.1016/j.devcel.2019.01.001. Epub 2019 Jan 31.]
* [https://ift.tt/31QR306 Kelley LC, Chi Q, Cáceres R, Hastie E, Schindler AJ, Jiang Y, Matus DQ, Plastino J, Sherwood DR. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs. Dev Cell. 2019 Feb 11;48(3):313-328.e8. doi: 10.1016/j.devcel.2018.12.018. Epub 2019 Jan 24.]
* [https://ift.tt/2KGCeYy Gordon KL, Payne SG, Linden-High LM, Pani AM, Goldstein B, Hubbard EJA, Sherwood DR. Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle. Curr Biol. 2019 Mar 4;29(5):823-833.e5. doi: 10.1016/j.cub.2019.01.056. Epub 2019 Feb 21.]
* [https://ift.tt/31TYvYF Katsura H, Kobayashi Y, Tata PR, Hogan BLM. IL-1and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019 Apr 9;12(4):657-666. doi: 10.1016/j.stemcr.2019.02.013. Epub 2019 Mar 28.]
* [https://ift.tt/2KJVuV7 Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, Liu F, Turner K, Yang H, Brunk E, Bi J, Furnari F, Bafna V, Ren B, Mischel PS. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019 May;569(7757):570-575. doi: 10.1038/s41586-019-1150-2. Epub 2019 Apr 24.]
* [https://ift.tt/31RSfRg <nowiki>Hartman JH, Richie CT, Gordon KL, Mello DF, Castillo P, Zhu A, Wang Y, Hoffer BJ, Sherwood DR, Meyer JN, Harvey BK. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. Eur J Cell Biol. 2019 May 21. pii: S0171-9335(18)30348-0. doi: 10.1016/j.ejcb.2019.05.002. [Epub ahead of print]</nowiki>]
* [https://ift.tt/2KK89at Kwak YH, Barrientos T, Furman B, Zhang H, Puviindran V, Cutcliffe H, Herfarth J, Nwankwo E, Alman BA. Pharmacologic targeting of β-catenin improves fracture healing in old mice. Sci Rep. 2019 Jun 21;9(1):9005. doi: 10.1038/s41598-019-45339-0.]
* [https://ift.tt/31Z1Buz E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D. An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. Neuron. 2018 Jan 3;97(1):125-138.e5. doi: 10.1016/j.neuron.2017.12.001.]
* [https://ift.tt/2KHZBRo Sherwood DR, Plastino J. Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo.Genetics. 2018 Jan;208(1):53-78. doi: 10.1534/genetics.117.300082. Review.]
* [https://ift.tt/31O5vpJ Koh S, Chen WJ, Dejneka NS, Harris IR, Lu B, Girman S, Saylor J, Wang S, Eroglu C. Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity. J Neurosci. 2018 Mar 21;38(12):2923-2943. doi: 10.1523/JNEUROSCI.1532-17.2018. Epub 2018 Feb 5.]
* [https://ift.tt/2KGCkiS Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA. Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051.]
* [https://ift.tt/31Q7XMx Wopat S, Bagwell J, Sumigray KD, Dickson AL, Huitema LFA, Poss KD, Schulte-Merker S, Bagnat M. Spine Patterning Is Guided by Segmentation of the Notochord Sheath. Cell Rep.2018 Feb 20;22(8):2026-2038. doi: 10.1016/j.celrep.2018.01.084.]
* [https://ift.tt/2KIvj16 Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell. 2018 Mar 26;44(6):679-693.e5. doi: 10.1016/j.devcel.2018.02.024.]
* [https://ift.tt/31NgrUD Tata A, Kobayashi Y, Chow RD, Tran J, Desai A, Massri AJ, McCord TJ, Gunn MD, Tata PR. Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. Cell Stem Cell. 2018 May 3;22(5):668-683.e6. doi: 10.1016/j.stem.2018.03.018. Epub 2018 Apr 12.]
* [https://ift.tt/2KGClTY Kobayashi Y, Tata PR. Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung. Dev Cell. 2018 May 21;45(4):425-426. doi: 10.1016/j.devcel.2018.05.009.]
* [https://ift.tt/31UEfWV Keeley DP, Sherwood DR. Tissue linkage through adjoining basement membranes: The long and the short term of it. Matrix Biol. 2019 Jan;75-76:58-71. doi: 10.1016/j.matbio.2018.05.009. Epub 2018 May 24. Review.]
* [https://ift.tt/31N66In Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA. Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13). pii: dev162396. doi: 10.1242/dev.162396.]
* [https://ift.tt/2KHdY8q Atik AF, Suryadevara CM, Schweller RM, West JL, Healy P, Herndon li JE, Congdon KL, Sanchez-Perez L, McLendon RE, Archer GE, Fecci P, Sampson JH. Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells. J Clin Neurosci.2018 Oct;56:163-168. doi: 10.1016/j.jocn.2018.06.005. Epub 2018 Jul 21.]
* [https://ift.tt/31TYy6N Cao J, Poss KD. The epicardium as a hub for heart regeneration. Nat Rev Cardiol. 2018 Oct;15(10):631-647. doi: 10.1038/s41569-018-0046-4. Review.]
* [https://ift.tt/2KGC8jq Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1.]
* [https://ift.tt/31TYzaR Karra R, Foglia MJ, Choi WY, Belliveau C, DeBenedittis P, Poss KD. Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8805-8810. doi: 10.1073/pnas.1722594115. Epub 2018 Aug 13.]
* [https://ift.tt/2KIbVRL Walton EM, Cronan MR, Cambier CJ, Rossi A, Marass M, Foglia MD, Brewer WJ, Poss KD, Stainier DYR, Bertozzi CR, Tobin DM. Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell Host Microbe. 2018 Oct 10;24(4):514-525.e6. doi: 10.1016/j.chom.2018.09.004.]
* [https://ift.tt/31KLGQ4 Cáceres R, Bojanala N, Kelley LC, Dreier J, Manzi J, Di Federico F, Chi Q, Risler T, Testa I, Sherwood DR, Plastino J. Forces drive basement membrane invasion in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11537-11542. doi: 10.1073/pnas.1808760115. Epub 2018 Oct 22.]
* [https://ift.tt/2KGCo26 Mokalled MH, Poss KD. A Regeneration Toolkit. Dev Cell. 2018 Nov 5;47(3):267-280. doi: 10.1016/j.devcel.2018.10.015.]
* [https://ift.tt/31QR3x8 Cox BD, De Simone A, Tornini VA, Singh SP, Di Talia S, Poss KD. In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone. Curr Biol. 2018 Dec 17;28(24):3937-3947.e4. doi: 10.1016/j.cub.2018.10.052. Epub 2018 Nov 29.]
* [https://ift.tt/2KGCoz8 Vi L, Baht GS, Soderblom EJ, Whetstone H, Wei Q, Furman B, Puviindran V, Nadesan P, Foster M, Poon R, White JP, Yahara Y, Ng A, Barrientos T, Grynpas M, Mosely MA,Alman BA. Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. Nat Commun. 2018 Dec 5;9(1):5191. doi: 10.1038/s41467-018-07666-0.]
* [https://ift.tt/31NRNTW Fernandez CE, Bakovic M, Karra R. Endothelial Contributions to Zebrafish Heart Regeneration. J Cardiovasc Dev Dis. 2018 Dec 11;5(4). pii: E56. doi: 10.3390/jcdd5040056. Review.]
* [https://ift.tt/2KGCp6a Juhas M, Abutaleb N, Wang JT, Ye J, Shaikh Z, Sriworarat C, Qian Y, Bursac N. Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration. Nat Biomed Eng. 2018 Dec;2(12):942-954. doi: 10.1038/s41551-018-0290-2. Epub 2018 Oct 1.]
* [https://ift.tt/31Q2OnS Goldman JA, Kuzu G, Lee N, Karasik J, Gemberling M, Foglia MJ, Karra R, Dickson AL, Sun F, Tolstorukov MY, Poss KD. Resolving Heart Regeneration by Replacement Histone Profiling. Dev Cell. 2017 Feb 27;40(4):392-404.e5. doi: 10.1016/j.devcel.2017.01.013.]
* [https://ift.tt/2KGCpDc Pilaz LJ, Silver DL. Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells. FEBS Lett. 2017 Jun;591(11):1526-1539. doi: 10.1002/1873-3468.12626. Epub 2017 Apr 6. Review.]
* [https://ift.tt/31N67Mr Li Y, Asfour H, Bursac N. Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Acta Biomater. 2017 Jun;55:120-130. doi: 10.1016/j.actbio.2017.04.027. Epub 2017 Apr 25.]
* [https://ift.tt/2KIbZ3X Jayadev R, Sherwood DR. Basement membranes. Curr Biol. 2017 Mar 20;27(6):R207-R211. doi: 10.1016/j.cub.2017.02.006.]
* [https://ift.tt/31TYF2d Schweller RM, Wu ZJ, Klitzman B, West JL. Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. Ann Biomed Eng. 2017 Jun;45(6):1387-1398. doi: 10.1007/s10439-017-1822-8. Epub 2017 Mar 30.]
* [https://ift.tt/2KGCqae Tzahor E, Poss KD. Cardiac regeneration strategies: Staying young at heart. Science. 2017 Jun 9;356(6342):1035-1039. doi: 10.1126/science.aam5894. Epub 2017 Jun 8. Review.]
* [https://ift.tt/31TYFzf Linden LM, Gordon KL, Pani AM, Payne SG, Garde A, Burkholder D, Chi Q, Goldstein B, Sherwood DR. Identification of regulators of germ stem cell enwrapment by its niche in C. elegans. Dev Biol. 2017 Sep 1;429(1):271-284. doi: 10.1016/j.ydbio.2017.06.019. Epub 2017 Jun 23.]
* [https://ift.tt/2KIc0F3 Karra R, Walter AO, Wu SM. The relationship between cardiac endothelium and fibroblasts: it's complicated. J Clin Invest. 2017 Aug 1;127(8):2892-2894. doi: 10.1172/JCI95492. Epub 2017 Jun 26.]
* [https://ift.tt/31TYHHn Tornini VA, Thompson JD, Allen RL, Poss KD. Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. Development. 2017 Aug 15;144(16):2889-2895. doi: 10.1242/dev.155655.]
* [https://ift.tt/2KGCruO Chen CH, Poss KD. Regeneration Genetics. Annu Rev Genet. 2017 Nov 27;51:63-82. doi: 10.1146/annurev-genet-120116-024554. Epub 2017 Aug 30. Review.]
* [https://ift.tt/31TYILr Kelley LC, Wang Z, Hagedorn EJ, Wang L, Shen W, Lei S, Johnson SA, Sherwood DR. Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans. Nat Protoc. 2017 Oct;12(10):2081-2096. doi: 10.1038/nprot.2017.093. Epub 2017 Sep 7.]
* [https://ift.tt/2KGCs1Q Jayadev R, Sherwood DR. Morphogenesis: Shaping Tissues through Extracellular Force Gradients. Curr Biol. 2017 Sep 11;27(17):R850-R852. doi: 10.1016/j.cub.2017.07.040.]
* [https://ift.tt/31P30DC Sawyer JK, Cohen E, Fox DT. Interorgan regulation of Drosophilaintestinal stem cell proliferation by a hybrid organ boundary zone.Development. 2017 Nov 15;144(22):4091-4102. doi: 10.1242/dev.153114. Epub 2017 Sep 25.]
* [https://ift.tt/2KGCt5U Cao, J., Wang, J., Jackman, C.P., Cox, A.H., Balowski, J.J., Cox, B.D., De Simone, A., Dickson, A.L., DiTalia, S.,Small, E.M., Kiehart, D.P., Bursac, N., Poss, K.D. Tension Creates Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue. Dev Cell. 2017 Sep 25;42(6):600-615.e4. doi: 10.1016/j.devcel.2017.08.024.]
* [https://ift.tt/31TYN1H Naegeli KM, Hastie E, Garde A, Wang Z, Keeley DP, Gordon KL, Pani AM, Kelley LC, Morrissey MA, Chi Q, Goldstein B, Sherwood DR. Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain. Dev Cell. 2017 Nov 20;43(4):403-417.e10. doi: 10.1016/j.devcel.2017.10.024.]
* [https://ift.tt/2KIc2g9 Konkimalla A, Tata PR. Plasticity in Olfactory Epithelium: Is It a Sniffer or Shape Shifter? Cell Stem Cell. 2017 Dec 7;21(6):707-708. doi: 10.1016/j.stem.2017.11.014.]
* [https://ift.tt/31KLHn6 Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 Dec 27;6. pii: e31683. doi: 10.7554/eLife.31683.]
August 20, 2019 at 03:56AM
