Saturday, October 5, 2019

Wallace B. Mendelson

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Wallace B. Mendelson

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'''Wallace B. Mendelson''' (born 22 March, 1945), is an American psychiatrist and author, working primarily in the fields of sleep research and psychopharmacology. He is best known for basic science studies elucidating the effects of inverse agonists of the benzodiazepine receptor<ref>Mendelson, W.B., Cain, M., Cook, J.M., Paul, S.M., and Skolnick, P.:  Do benzodiazepine receptors play a role in sleep regulation?  Studies with the benzodiazepine antagonist 3 hydroxymethy lBcarboline.  In Beta Carbolines and Tetrahydroisoquinolones.  (Usdin, E., ed.), Alan R. Liss, New York, 1982, pp. 253261.</ref>, the actions of endogenous ligands for benzodiazepine receptors <ref>Mullen, K.D., Maftin, J.V., Mendelson, W.B., Jones, E.A.: Further evidence that hepatic encephalopathy in the galactosamine rabbit model may be mediated by an endogenous benzodiazepine compound. In: Advances in ammonia  metabolism and hepatic       encephalopathy(PB Soeters, JHP Wilson, AJ Meijer, E  Holm, eds.), Elsevier Science Publishers, pp.333-337, 1988.</ref>, and the role of the medial preoptic area in pharmacologic sleep induction<ref>Mendelson, W.B.: The sleep-inducing effect of ethanol microinjection into the medial preoptic area is blocked by flumazenil. Brain Res. 892: 118-121, 2001.</ref>.  At a human level he characterized differences in regulation of growth hormone secretion during sleep and waking<ref>Mendelson, W.B., Jacobs, L.S., Gillin, J.C., and Wyatt, R.J.: The regulation of insulin induced and sleep related human growth hormone secretion. Psychoneuroendocrinology, 4: 341-349,1980.</ref>, effects of drugs on the perception of being awake or asleep<ref>Mendelson, W.B. Pharmacologic  alteration of the perception of being awake or asleep. Sleep, 16(7): 641-646, 1993</ref>, and the clinical properties of sleep-inducing medicines<ref>Mendelson, W.B.: Subjective vs. objective tolerance during chronic administration of triazolam. Clinical Drug Investigation 10: 276-279, 1995.</ref>. He is the author of numerous papers and seven books in the fields of sleep science and pharmacology, and the founder of three accredited fellowship programs in sleep medicine. Recent book reviews have described him as 'an ardent and inspiring leader and teacher in the development of sleep medicine as a legitimate field of research and clinical care'<ref></ref> and 'a pioneer in the field of sleep research and sleep medicine, and … a well-respected psychiatrist, scientist, and sleep educator'.<ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref>

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October 06, 2019 at 12:35AM

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